› 5ha0

X-ray diffraction
1.44Å resolution

Crystal structure of the LTBP1 leukotriene d4 complex

Released:
DOI: 10.2210/pdb5ha0/pdb
PDB entry 5ha0 coloured by chain, front view.
PDB entry 5ha0 coloured by chain, side view.
PDB entry 5ha0 coloured by chain, top view.
Source organism: Rhodnius prolixus
Primary publication:
Structure and Ligand-Binding Mechanism of a Cysteinyl Leukotriene-Binding Protein from a Blood-Feeding Disease Vector.
Jablonka W, Pham V, Nardone G, Gittis A, Silva-Cardoso L, Atella GC, Ribeiro JM, Andersen JF
ACS Chem Biol 11 1934-44 (2016)
PMID: 27124118

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182211 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lipocalin AI-4 Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 16.9 KDa
Source organism: Rhodnius prolixus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7YT09 (Residues: 18-173; Coverage: 100%)
Sequence domains: Triabin
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand LTD 1 x LTD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 34.402Å b: 58.299Å c: 36.039Å
α: 90° β: 104.14° γ: 90°
R-values:
R R work R free
0.161 0.16 0.188
Expression system: Escherichia coli

Quick links

Citations

1 review citation

An Overview of D7 Protein Structure and Physiological Roles in Blood-Feeding Nematocera.
Alvarenga et al. (2022)
4 other articles

2 mentions without citation

Evidence that immunization with TP0751, a bipartite Treponema pallidum lipoprotein with an intrinsically disordered region and lipocalin fold, fails to protect in the rabbit model of experimental syphilis.
Luthra et al. (2020)
1 more