› 5hgu

X-ray diffraction
2.05Å resolution

Crystal structure of human transcription factor TEAD2 in complex with palmitate

Released:
DOI: 10.2210/pdb5hgu/pdb
PDB entry 5hgu coloured by chain, front view.
PDB entry 5hgu coloured by chain, side view.
PDB entry 5hgu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway.
Chan P, Han X, Zheng B, DeRan M, Yu J, Jarugumilli GK, Deng H, Pan D, Luo X, Wu X
Nat Chem Biol 12 282-9 (2016)
PMID: 26900866

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172328 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional enhancer factor TEF-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 237 amino acids
Theoretical weight: 27.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15562 (Residues: 217-447; Coverage: 52%)
Gene names: TEAD2, TEF4
Sequence domains: YAP binding domain
Structure domains: Coagulation Factor XIII; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand PLM 2 x PLM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 122.486Å b: 61.146Å c: 80.307Å
α: 90° β: 117.17° γ: 90°
R-values:
R R work R free
0.187 0.185 0.222
Expression system: Escherichia coli

Quick links

Citations

62 review citations

The Hippo Signaling Pathway in Development and Disease.
Zheng et al. (2019)
61 more

8 mentions without citation

Protein-Protein Interaction Disruptors of the YAP/TAZ-TEAD Transcriptional Complex.
Pobbati et al. (2020)
7 more