5hh0

X-ray diffraction
1.6Å resolution

Crystal structure of human Naa60 in complex with CoA

Released:

Function and Biology Details

Reactions catalysed:
Acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-190668 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-alpha-acetyltransferase 60 Chain: A
Molecule details ›
Chain: A
Length: 200 amino acids
Theoretical weight: 22.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H7X0 (Residues: 1-199; Coverage: 82%)
Gene names: HAT4, NAA60, NAT15, UNQ2771/PRO7155
Sequence domains: Acetyltransferase (GNAT) family

Ligands and Environments


Cofactor: Ligand COA 1 x COA
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 67.1Å b: 73.437Å c: 43.165Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.181 0.184
Expression system: Escherichia coli