Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Gremlin-2 and Growth/differentiation factor 5 (preferred)
PDBe Complex ID:
PDB-CPX-131532 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gremlin-2
Molecule details ›
Chains: E, F, G, H
Length: 147 amino acids
Theoretical weight: 17.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains: DAN domain
Structure domains: Cystine-knot cytokines
Length: 147 amino acids
Theoretical weight: 17.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
O88273 (Residues: 22-168; Coverage: 100%)
Sequence domains: DAN domain
Structure domains: Cystine-knot cytokines
Growth/differentiation factor 5
Molecule details ›
Chains: A, B, C, D
Length: 120 amino acids
Theoretical weight: 13.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Length: 120 amino acids
Theoretical weight: 13.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P43026 (Residues: 382-501; Coverage: 25%)
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 23-ID-D
Expression system: Escherichia coli
