› 5hpp

X-ray diffraction
2.08Å resolution

Crystal structure of a macrocyclic beta-sheet peptide derived from transthyretin (106-121) - (ORN)TIA(MAA)LLS(ORN)S(PHI)STTAV

Released:
DOI: 10.2210/pdb5hpp/pdb
PDB entry 5hpp coloured by chain, front view.
PDB entry 5hpp coloured by chain, side view.
PDB entry 5hpp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Square channels formed by a peptide derived from transthyretin.
Yoo S, Kreutzer AG, Truex NL, Nowick JS
Chem Sci 7 6946-6951 (2016)
PMID: 28451128

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-165748 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ORN-THR-ILE-ALA-MAA-LEU-LEU-SER-ORN-SER-PHI-SER-THR-THR-ALA-VAL Chain: A
Molecule details ›
Chain: A
Length: 16 amino acids
Theoretical weight: 1.75 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
3 modified residues:
Ligand ORN 2 x ORN
Ligand MAA 1 x MAA
Ligand PHI 1 x PHI

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-003
Spacegroup: P43212
Unit cell:
a: 42.3Å b: 42.3Å c: 16.32Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.159 0.184
Expression system: Not provided

Quick links

Citations

6 citation in other articles

Stabilization, Assembly, and Toxicity of Trimers Derived from Aβ.
Kreutzer et al. (2017)
5 more

4 mentions without citation

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.
Judson et al. (2015)
3 more