› 5hu4

X-ray diffraction
2.3Å resolution

Cystal structure of listeria monocytogenes sortase A

Released:
DOI: 10.2210/pdb5hu4/pdb
PDB entry 5hu4 coloured by chain, front view.
PDB entry 5hu4 coloured by chain, side view.
PDB entry 5hu4 coloured by chain, top view.
Source organism: Listeria monocytogenes
Primary publication:
Inhibition of sortase A by chalcone prevents Listeria monocytogenes infection.
Li H, Chen Y, Zhang B, Niu X, Song M, Luo Z, Lu G, Liu B, Zhao X, Wang J, Deng X
Biochem Pharmacol 106 19-29 (2016)
PMID: 26826492

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187001 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sortase A Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 16.11 KDa
Source organism: Listeria monocytogenes
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8Y8H5 (Residues: 78-222; Coverage: 65%)
Gene names: lmo0929, srtA
Sequence domains: Sortase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL19U1
Spacegroup: P212121
Unit cell:
a: 36.986Å b: 56.599Å c: 60.548Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.234 0.274
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Targeting Bacterial Sortases in Search of Anti-Virulence Therapies with Low Risk of Resistance Development.
Nitulescu et al. (2021)
1 more

2 mentions without citation

Sequence variation in the β7-β8 loop of bacterial class A sortase enzymes alters substrate selectivity.
Piper et al. (2021)
1 more