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› 5hup

X-ray diffraction
3.42Å resolution

Crystal Structure of NadC from Streptococcus pyogenes

Released:
DOI: 10.2210/pdb5hup/pdb
Model geometry
Fit model/data
PDB entry 5hup coloured by chain, front view.
PDB entry 5hup coloured by chain, side view.
PDB entry 5hup coloured by chain, top view.
Source organism: Streptococcus pyogenes MGAS10750
Primary publication:
Streptococcus pyogenes quinolinate-salvage pathway-structural and functional studies of quinolinate phosphoribosyl transferase and NH3 -dependent NAD+ synthetase.
Booth WT, Morris TL, Mysona DP, Shah MJ, Taylor LK, Karlin TW, Clary K, Majorek KA, Offermann LR, Chruszcz M
FEBS J 284 2425-2441 (2017)
PMID: 28618168

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-245240 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nicotinate-nucleotide pyrophosphorylase (Carboxylating) Chains: A, B, C, E, F, H
Molecule details ›
Chains: A, B, C, E, F, H
Length: 315 amino acids
Theoretical weight: 34.5 KDa
Source organism: Streptococcus pyogenes MGAS10750
Expression system: Escherichia coli BL21(DE3)
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 17 x SO4
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2221
Unit cell:
a: 108.149Å b: 188.816Å c: 222.181Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.233 0.294
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

A structural perspective on the PP-loop ATP pyrophosphatase family.
Fellner et al. (2018)
1 other article

1 mention without citation

Streptococcus pyogenes quinolinate-salvage pathway-structural and functional studies of quinolinate phosphoribosyl transferase and NH3 -dependent NAD+ synthetase.
Booth et al. (2017)