› 5hvx

X-ray diffraction
2.45Å resolution

Full length Wild-Type Open-form Sodium Channel NavMs

Released:
DOI: 10.2210/pdb5hvx/pdb
PDB entry 5hvx coloured by chain, front view.
PDB entry 5hvx coloured by chain, side view.
PDB entry 5hvx coloured by chain, top view.
Source organism: Magnetococcus marinus MC-1
Primary publication:
The complete structure of an activated open sodium channel.
Sula A, Booker J, Ng LC, Naylor CE, DeCaen PG, Wallace BA
Nat Commun 8 14205 (2017)
PMID: 28205548

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106115 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.22 KDa
Source organism: Magnetococcus marinus MC-1
Expression system: Escherichia coli
UniProt:
  • Canonical: A0L5S6 (Residues: 1-274; Coverage: 100%)
Gene name: Mmc1_0798
Sequence domains: Ion transport protein

Ligands and Environments

5 bound ligands:
Ligand NA 3 x NA
Ligand 2CV 1 x 2CV
Ligand 12P 1 x 12P
Ligand EDO 1 x EDO
Ligand MES 2 x MES
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SOLEIL BEAMLINE PROXIMA 1
Spacegroup: I422
Unit cell:
a: 109Å b: 109Å c: 210.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.207 0.233
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7.
Mulcahy et al. (2019)
18 more

20 mentions without citation

Interpreting the functional role of a novel interaction motif in prokaryotic sodium channels.
Sula et al. (2017)
19 more