› 5i3a

X-ray diffraction
2.2Å resolution

Crystal Structure of tyrosinase from Bacillus megaterium with configuration A of hydroquinone inhibitor in the active site

Released:
DOI: 10.2210/pdb5i3a/pdb
Model geometry
Fit model/data
PDB entry 5i3a coloured by chain, front view.
PDB entry 5i3a coloured by chain, side view.
PDB entry 5i3a coloured by chain, top view.
Source organism: Priestia megaterium
Primary publication:
The unravelling of the complex pattern of tyrosinase inhibition.
Deri B, Kanteev M, Goldfeder M, Lecina D, Guallar V, Adir N, Fishman A
OpenAccess logo Sci Rep 6 34993 (2016)
PMID: 27725765

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109772 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosinase copper-binding domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 33.29 KDa
Source organism: Priestia megaterium
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: B2ZB02 (Residues: 4-290; Coverage: 97%)
Sequence domains: Common central domain of tyrosinase
Structure domains: Di-copper center containing domain from catechol oxidase

Ligands and Environments

2 bound ligands:
Ligand ZN 5 x ZN
Ligand HQE 2 x HQE
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 69.648Å b: 74.36Å c: 120.91Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.229
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

A comprehensive review on tyrosinase inhibitors.
Zolghadri et al. (2019)
8 more

1 mention without citation

The unravelling of the complex pattern of tyrosinase inhibition.
Deri et al. (2016)