Function and Biology Details
Reaction catalysed:
Similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Procathepsin L (preferred)
PDBe Complex ID:
PDB-CPX-139719 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cathepsin L heavy chain
Molecule details ›
Chain: A
Length: 106 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
Sequence domains: Papain family cysteine protease
Length: 106 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
- Canonical:
P07711 (Residues: 113-218; Coverage: 34%)
Sequence domains: Papain family cysteine protease
Cathepsin L heavy chain
Molecule details ›
Chain: B
Length: 112 amino acids
Theoretical weight: 12.33 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
Sequence domains: Papain family cysteine protease
Length: 112 amino acids
Theoretical weight: 12.33 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
- Canonical: P07711 (Residues: 222-333; Coverage: 35%)
Sequence domains: Papain family cysteine protease
