› 5id3

Solution NMR

Solution structure of the pore-forming region of C. elegans Mitochondrial Calcium Uniporter (MCU)

Released:
DOI: 10.2210/pdb5id3/pdb
PDB entry 5id3 coloured by chain, ensemble of 15 models, front view.
PDB entry 5id3 coloured by chain, ensemble of 15 models, side view.
PDB entry 5id3 coloured by chain, ensemble of 15 models, top view.
Source organism: Caenorhabditis elegans
Primary publication:
Architecture of the mitochondrial calcium uniporter.
Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ
Nature 533 269-73 (2016)
PMID: 27135929

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173132 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium uniporter protein, mitochondrial Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 159 amino acids
Theoretical weight: 18.93 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q21121 (Residues: 167-318; Coverage: 46%)
Gene names: K02B2.3, mcu-1
Sequence domains: Mitochondrial calcium uniporter

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 6%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

62 review citations

The machineries, regulation and cellular functions of mitochondrial calcium.
Giorgi et al. (2018)
61 more

9 mentions without citation

Mitochondrial Ca2+ transport in the endothelium: regulation by ions, redox signalling and mechanical forces.
Alevriadou et al. (2017)
8 more