› 5ie8

Solution NMR

The pyrazinoic acid binding domain of Ribosomal Protein S1 from Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb5ie8/pdb
PDB entry 5ie8 coloured by chain, ensemble of 2 models, front view.
PDB entry 5ie8 coloured by chain, ensemble of 2 models, side view.
PDB entry 5ie8 coloured by chain, ensemble of 2 models, top view.
Source organism: Mycobacterium leprae TN
Primary publication:
(1)H, (15)N, (13)C resonance assignments for pyrazinoic acid binding domain of ribosomal protein S1 from Mycobacterium tuberculosis.
Huang B, Fu J, Guo C, Wu X, Lin D, Liao X
Biomol NMR Assign 10 321-4 (2016)
PMID: 27412769

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155516 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Small ribosomal subunit protein bS1 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 9.99 KDa
Source organism: Mycobacterium leprae TN
Expression system: Enterobacteria phage L1
UniProt:
  • Canonical: P46836 (Residues: 280-368; Coverage: 19%)
Gene names: ML1382, rpsA
Sequence domains: S1 RNA binding domain
Structure domains: Nucleic acid-binding proteins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: simulated annealing
Expression system: Enterobacteria phage L1

Quick links

Citations

3 citation in other articles

Introducing RpsA Point Mutations Δ438A and D123A into the Chromosome of Mycobacterium tuberculosis Confirms Their Role in Causing Resistance to Pyrazinamide.
Shi et al. (2019)
2 more

1 mention without citation

Structure-Guided Computational Approaches to Unravel Druggable Proteomic Landscape of Mycobacterium leprae.
Vedithi et al. (2021)