› 5igl

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184977 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription initiation factor TFIID subunit 1-like Chain: A
Molecule details ›
Chain: A
Length: 155 amino acids
Theoretical weight: 18.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IZX4 (Residues: 1523-1654; Coverage: 7%)
Gene name: TAF1L
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand BMF 1 x BMF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: I212121
Unit cell:
a: 44.172Å b: 89.177Å c: 117.892Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.211 0.294
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials.
Cheng et al. (2019)
6 more

1 mention without citation

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.
Picaud et al. (2016)