› 5ik5

X-ray diffraction
1.39Å resolution

Laminin A2LG45 C-form, G6/7 bound.

Released:
DOI: 10.2210/pdb5ik5/pdb
PDB entry 5ik5 coloured by chain, front view.
PDB entry 5ik5 coloured by chain, side view.
PDB entry 5ik5 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of laminin binding to the LARGE glycans on dystroglycan.
Briggs DC, Yoshida-Moriguchi T, Zheng T, Venzke D, Anderson ME, Strazzulli A, Moracci M, Yu L, Hohenester E, Campbell KP
Nat Chem Biol 12 810-4 (2016)
PMID: 27526028

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178803 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Laminin subunit alpha-2 Chain: A
Molecule details ›
Chain: A
Length: 393 amino acids
Theoretical weight: 42.63 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q60675 (Residues: 2730-3118; Coverage: 13%)
Gene name: Lama2
Sequence domains:
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: A2G, GAL
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: BDP, XYS
Carbohydrate polymer
3 bound ligands:
Ligand CA 2 x CA
Ligand GOL 6 x GOL
Ligand 4MU 1 x 4MU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2221
Unit cell:
a: 70.39Å b: 110.74Å c: 123.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.15 0.149 0.177
Expression system: Homo sapiens

Quick links

Citations

17 review citations

Virus recognition of glycan receptors.
Thompson et al. (2019)
16 more

5 mentions without citation

Structural biology of laminins.
Hohenester E. (2019)
4 more