› 5ilu

X-ray diffraction
1.1Å resolution

Autoinhibited ETV4

Released:
DOI: 10.2210/pdb5ilu/pdb
PDB entry 5ilu coloured by chain, front view.
PDB entry 5ilu coloured by chain, side view.
PDB entry 5ilu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Currie SL, Lau DKW, Doane JJ, Whitby FG, Okon M, McIntosh LP, Graves BJ
Nucleic Acids Res 45 2223-2241 (2017)
PMID: 28161714

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-155018 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ETS translocation variant 4 Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 11.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43268 (Residues: 340-436; Coverage: 20%)
Gene names: E1AF, ETV4, PEA3
Sequence domains: Ets-domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P3121
Unit cell:
a: 50.866Å b: 50.866Å c: 68.621Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.173 0.194
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Function and regulation of the PEA3 subfamily of ETS transcription factors in cancer.
Qi et al. (2020)
3 more

2 mentions without citation

Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Currie et al. (2017)
1 more