› 5ilv

X-ray diffraction
1.8Å resolution

Uninhibited ETV5

Released:
DOI: 10.2210/pdb5ilv/pdb
PDB entry 5ilv coloured by chain, front view.
PDB entry 5ilv coloured by chain, side view.
PDB entry 5ilv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Currie SL, Lau DKW, Doane JJ, Whitby FG, Okon M, McIntosh LP, Graves BJ
Nucleic Acids Res 45 2223-2241 (2017)
PMID: 28161714

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-154254 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ETS translocation variant 5 Chain: A
Molecule details ›
Chain: A
Length: 92 amino acids
Theoretical weight: 10.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P41161 (Residues: 366-457; Coverage: 18%)
Gene names: ERM, ETV5
Sequence domains: Ets-domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2221
Unit cell:
a: 57.371Å b: 65.611Å c: 52.677Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.186 0.234
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Function and regulation of the PEA3 subfamily of ETS transcription factors in cancer.
Qi et al. (2020)
3 more

2 mentions without citation

Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5.
Currie et al. (2017)
1 more