› 5irz

Electron Microscopy
3.28Å resolution

Structure of TRPV1 determined in lipid nanodisc

Released:
DOI: 10.2210/pdb5irz/pdb
PDB entry 5irz coloured by chain, front view.
PDB entry 5irz coloured by chain, side view.
PDB entry 5irz coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Gao Y, Cao E, Julius D, Cheng Y
Nature 534 347-51 (2016)
PMID: 27281200
Related structures: EMD-8118

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128685 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 1 Chains: B, C, D, E
Molecule details ›
Chains: B, C, D, E
Length: 636 amino acids
Theoretical weight: 72.96 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: O35433 (Residues: 110-764; Coverage: 75%)
Gene names: Trpv1, Vr1, Vr1l
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand 6O8 4 x 6O8
Ligand 6ES 4 x 6ES
Ligand 6OE 16 x 6OE
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.28Å
Relevant EMDB volumes: EMD-8118
Expression system: Homo sapiens

Quick links

Citations

122 review citations

Nanodiscs in Membrane Biochemistry and Biophysics.
Denisov et al. (2017)
121 more

61 mentions without citation

Metabolism of the Endocannabinoid Anandamide: Open Questions after 25 Years.
Maccarrone M. (2017)
60 more