› 5iwr

X-ray diffraction
3.85Å resolution

Structure of Transient Receptor Potential (TRP) channel TRPV6 in the presence of barium

Released:
DOI: 10.2210/pdb5iwr/pdb
PDB entry 5iwr coloured by chain, front view.
PDB entry 5iwr coloured by chain, side view.
PDB entry 5iwr coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the epithelial calcium channel TRPV6.
Saotome K, Singh AK, Yelshanskaya MV, Sobolevsky AI
Nature 534 506-11 (2016)
PMID: 27296226

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193089 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 6 Chain: A
Molecule details ›
Chain: A
Length: 672 amino acids
Theoretical weight: 77.15 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9R186 (Residues: 41-709; Coverage: 87%)
Gene name: Trpv6
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand BA 4 x BA
Ligand DTB 1 x DTB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P4212
Unit cell:
a: 144.35Å b: 144.35Å c: 113.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.285 0.283 0.323
Expression system: Homo sapiens

Quick links

Citations

38 review citations

Understand spiciness: mechanism of TRPV1 channel activation by capsaicin.
Yang et al. (2017)
37 more

7 mentions without citation

Structural mechanisms of transient receptor potential ion channels.
Cao E. (2020)
6 more