› 5iy3

X-ray diffraction
2.2Å resolution

Zika Virus Non-structural Protein NS1

Released:
DOI: 10.2210/pdb5iy3/pdb
PDB entry 5iy3 coloured by chain, front view.
PDB entry 5iy3 coloured by chain, side view.
PDB entry 5iy3 coloured by chain, top view.
Source organism: Zika virus
Primary publication:
Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses.
Song H, Qi J, Haywood J, Shi Y, Gao GF
Nat Struct Mol Biol 23 456-8 (2016)
PMID: 27088990

Function and Biology Details

Reactions catalysed: 
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102845 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Genome polyprotein Chains: A, B
Molecule details ›
Chains: A, B
Length: 181 amino acids
Theoretical weight: 20.77 KDa
Source organism: Zika virus
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A109PRQ3 (Residues: 966-1146; Coverage: 5%)
Sequence domains: Flavivirus non-structural Protein NS1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 63.868Å b: 103.755Å c: 114.843Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.205 0.246
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Congenital Viral Infection: Traversing the Uterine-Placental Interface.
Pereira L. (2018)
24 more

13 mentions without citation

The A-Z of Zika drug discovery.
Mottin et al. (2018)
12 more