Function and Biology Details
Reactions catalysed:
RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate.
L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA +H(+).
ATP + H2O = ADP + phosphate + H(+).
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- RNA polymerase II, heptapeptide repeat, eukaryotic
- TATA-box binding protein
- Transcription factor TFIIB
- Zinc finger, TFIIS-type
- Transcription factor IIA, beta-barrel
- Transcription factor IIA, alpha/beta subunit
- DNA-directed RNA polymerases I, II, and III subunit RPABC3
- Nucleic acid-binding, OB-fold
101 more domains
Structure analysis Details
Assembly composition:
hetero 23-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-118820 (preferred)
Entry contents:
21 distinct polypeptide molecules
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (23 distinct):
DNA-directed RNA polymerase II subunit RPB1
Molecule details ›
Chain: A
Length: 1970 amino acids
Theoretical weight: 217.42 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 1970 amino acids
Theoretical weight: 217.42 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P24928 (Residues: 1-1970; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase II subunit RPB2
Molecule details ›
Chain: B
Length: 1174 amino acids
Theoretical weight: 134.07 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 1174 amino acids
Theoretical weight: 134.07 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P30876 (Residues: 1-1174; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase II subunit RPB3
DNA-directed RNA polymerase II subunit RPB4
DNA-directed RNA polymerases I, II, and III subunit RPABC1
DNA-directed RNA polymerases I, II, and III subunit RPABC2
DNA-directed RNA polymerase II subunit RPB7
DNA-directed RNA polymerases I, II, and III subunit RPABC3
DNA-directed RNA polymerase II subunit RPB9
DNA-directed RNA polymerases I, II, and III subunit RPABC5
DNA-directed RNA polymerase II subunit RPB11-a
DNA-directed RNA polymerases I, II, and III subunit RPABC4
Transcription initiation factor IIB
Transcription initiation factor IIA subunit 1
Transcription initiation factor IIA subunit 2
TATA-box-binding protein
General transcription factor IIE subunit 1
Transcription initiation factor IIE subunit beta
General transcription factor IIF subunit 1
General transcription factor IIF subunit 2
Transcription elongation factor A protein 1
