Function and Biology Details
Reactions catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Glycoprotein E, immunoglobulin-like domain, flavivirus
- Envelope glycoprotein M, flavivirus
- Envelope glycoprotein M superfamily, flavivirus
- Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily
- Flavivirus envelope glycoprotein E, Stem/Anchor domain
- Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily
- Immunoglobulin E-set
- Flaviviral glycoprotein E, central domain, subdomain 1
4 more domains
Structure analysis Details
Assembly composition:
hetero 360-mer (preferred)
Assembly name:
RNA-directed RNA polymerase NS5 (preferred)
PDBe Complex ID:
PDB-CPX-100068 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Envelope protein E
Molecule details ›
Chains: A, B, C
Length: 504 amino acids
Theoretical weight: 54.44 KDa
Source organism: Zika virus
UniProt:
Length: 504 amino acids
Theoretical weight: 54.44 KDa
Source organism: Zika virus
UniProt:
- Canonical:
A0A024B7W1 (Residues: 291-794; Coverage: 15%)
- Flavivirus glycoprotein, central and dimerisation domains
- Flavivirus glycoprotein, immunoglobulin-like domain
- Flavivirus envelope glycoprotein E, stem/anchor domain
Small envelope protein M
Molecule details ›
Chains: D, E, F
Length: 75 amino acids
Theoretical weight: 8.5 KDa
Source organism: Zika virus
UniProt:
Structure domains: Flavivirus envelope glycoprotein M-like
Length: 75 amino acids
Theoretical weight: 8.5 KDa
Source organism: Zika virus
UniProt:
- Canonical: A0A024B7W1 (Residues: 216-290; Coverage: 2%)
Structure domains: Flavivirus envelope glycoprotein M-like
