› 5j67

X-ray diffraction
3.16Å resolution

Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development

Released:
DOI: 10.2210/pdb5j67/pdb
PDB entry 5j67 coloured by chain, front view.
PDB entry 5j67 coloured by chain, side view.
PDB entry 5j67 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.
Ni T, Harlos K, Gilbert R
Open Biol 6 (2016)
PMID: 27249642

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130839 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Astrotactin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 572 amino acids
Theoretical weight: 65.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75129 (Residues: 768-1339; Coverage: 44%)
Gene names: ASTN2, KIAA0634
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 4 x NAG
Ligand I3P 4 x I3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P1
Unit cell:
a: 101.24Å b: 108.19Å c: 111.36Å
α: 87.18° β: 84.5° γ: 65.67°
R-values:
R R work R free
0.235 0.233 0.259
Expression system: Homo sapiens

Quick links

Citations

4 review citations

Cleave but not leave: Astrotactin proteins in development and disease.
Chang H. (2017)
3 more

1 mention without citation

Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms.
Ni et al. (2017)