› 5j68

X-ray diffraction
5.22Å resolution

Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development

Released:
DOI: 10.2210/pdb5j68/pdb
PDB entry 5j68 coloured by chain, front view.
PDB entry 5j68 coloured by chain, side view.
PDB entry 5j68 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.
Ni T, Harlos K, Gilbert R
Open Biol 6 (2016)
PMID: 27249642

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130839 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Astrotactin-2 Chain: A
Molecule details ›
Chain: A
Length: 572 amino acids
Theoretical weight: 65.05 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O75129 (Residues: 768-1339; Coverage: 44%)
Gene names: ASTN2, KIAA0634
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
2 bound ligands:
Ligand NAG 1 x NAG
Ligand I3P 1 x I3P
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P41212
Unit cell:
a: 103.9Å b: 103.9Å c: 304.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.348 0.348 0.364
Expression system: Homo sapiens

Quick links

Citations

5 review citations

Perforin-A key (shaped) weapon in the immunological arsenal.
Spicer et al. (2017)
4 more