› 5j8v

Electron Microscopy
4.9Å resolution

Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion

Released:
DOI: 10.2210/pdb5j8v/pdb
PDB entry 5j8v coloured by chain, front view.
PDB entry 5j8v coloured by chain, side view.
PDB entry 5j8v coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1.
Wei R, Wang X, Zhang Y, Mukherjee S, Zhang L, Chen Q, Huang X, Jing S, Liu C, Li S, Wang G, Xu Y, Zhu S, Williams AJ, Sun F, Yin CC
Cell Res 26 977-94 (2016)
PMID: 27573175
Related structures: EMD-8073

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145903 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ryanodine receptor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 5037 amino acids
Theoretical weight: 565.91 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P11716 (Residues: 1-5037; Coverage: 100%)
Gene name: RYR1
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.9Å
Relevant EMDB volumes: EMD-8073

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Citations

15 review citations

Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.
Bagur et al. (2017)
14 more

4 mentions without citation

Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies.
Ogawa et al. (2021)
3 more