› 5jei

X-ray diffraction
1.23Å resolution

Crystal structure of the GluA2 LBD in complex with FW

Released:
DOI: 10.2210/pdb5jei/pdb
PDB entry 5jei coloured by chain, front view.
PDB entry 5jei coloured by chain, side view.
PDB entry 5jei coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Mechanism of partial agonism in AMPA-type glutamate receptors.
Salazar H, Eibl C, Chebli M, Plested A
Nat Commun 8 14327 (2017)
PMID: 28211453

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 264 amino acids
Theoretical weight: 29.28 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-527, 653-797; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

9 bound ligands:
Ligand FWD 1 x FWD
Ligand PO4 2 x PO4
Ligand PG4 2 x PG4
Ligand PEG 3 x PEG
Ligand TOE 1 x TOE
Ligand PG0 1 x PG0
Ligand ETE 2 x ETE
Ligand EDO 1 x EDO
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P21212
Unit cell:
a: 126.465Å b: 44.425Å c: 47.276Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.122 0.121 0.147
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins.
Greger et al. (2017)
2 more

2 mentions without citation

Mechanism of partial agonism in AMPA-type glutamate receptors.
Salazar et al. (2017)
1 more