Function and Biology Details
Reaction catalysed:
(1a) a [histone H3]-N(6),N(6)-dimethyl-L-lysine(36) + 2-oxoglutarate + O(2) = a [histone H3]-N(6)-methyl-L-lysine(36) + succinate + formaldehyde + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-159040 (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Lysine-specific demethylase 2B
Molecule details ›
Chain: A
Length: 281 amino acids
Theoretical weight: 32.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: F-box-like
Length: 281 amino acids
Theoretical weight: 32.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q8NHM5 (Residues: 1059-1336; Coverage: 21%)
Sequence domains: F-box-like
S-phase kinase-associated protein 1
Molecule details ›
Chain: B
Length: 162 amino acids
Theoretical weight: 18.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Potassium Channel Kv1.1; Chain A
Length: 162 amino acids
Theoretical weight: 18.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P63208 (Residues: 2-163; Coverage: 99%)
Sequence domains:
Structure domains: Potassium Channel Kv1.1; Chain A
Polycomb group RING finger protein 1
Molecule details ›
Chain: C
Length: 109 amino acids
Theoretical weight: 13.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: RAWUL domain RING finger- and WD40-associated ubiquitin-like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Length: 109 amino acids
Theoretical weight: 13.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q9BSM1 (Residues: 150-255; Coverage: 41%)
Sequence domains: RAWUL domain RING finger- and WD40-associated ubiquitin-like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
BCL-6 corepressor-like protein 1
Molecule details ›
Chain: D
Length: 122 amino acids
Theoretical weight: 14.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: BCORL-PCGF1-binding domain
Length: 122 amino acids
Theoretical weight: 14.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: Q5H9F3 (Residues: 1668-1785; Coverage: 7%)
Sequence domains: BCORL-PCGF1-binding domain
