› 5ji1

X-ray diffraction
2.25Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126653 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth/differentiation factor 8 Chains: A, B
Molecule details ›
Chains: A, B
Length: 109 amino acids
Theoretical weight: 12.42 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: O08689 (Residues: 268-376; Coverage: 31%)
Gene names: Gdf8, Mstn
Sequence domains: Transforming growth factor beta like domain

Ligands and Environments

1 bound ligand:
Ligand MPD 7 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 29.606Å b: 77.739Å c: 119.544Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.235 0.277
Expression system: Cricetulus griseus

Quick links

Citations

14 review citations

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis.
Walton et al. (2017)
13 more

2 mentions without citation

Structural basis for potency differences between GDF8 and GDF11.
Walker et al. (2017)
1 more