› 5jpl

Solution NMR

LP2006, a handcuff-topology lasso peptide antibiotic

Released:
DOI: 10.2210/pdb5jpl/pdb
PDB entry 5jpl coloured by chain, ensemble of 20 models, front view.
PDB entry 5jpl coloured by chain, ensemble of 20 models, side view.
PDB entry 5jpl coloured by chain, ensemble of 20 models, top view.
Source organism: Nocardiopsis alba ATCC BAA-2165
Primary publication:
A new genome-mining tool redefines the lasso peptide biosynthetic landscape.
Tietz JI, Schwalen CJ, Patel PS, Maxson T, Blair PM, Tai HC, Zakai UI, Mitchell DA
Nat Chem Biol 13 470-478 (2017)
PMID: 28244986

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125350 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lasso RiPP family leader peptide-containing protein Chain: A
Molecule details ›
Chain: A
Length: 17 amino acids
Theoretical weight: 2.03 KDa
Source organism: Nocardiopsis alba ATCC BAA-2165
UniProt:
  • Canonical: J7LF03 (Residues: 30-46; Coverage: 37%)
Gene name: B005_3667

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 55%
Refinement method: simulated annealing

Quick links

Citations

53 review citations

New developments in RiPP discovery, enzymology and engineering.
Montalbán-López et al. (2021)
52 more

5 mentions without citation

Genome mining for lasso peptides: past, present, and future.
Cheung-Lee et al. (2019)
4 more