Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Anaphylatoxin, complement system domain
- Netrin module, non-TIMP type
- Tissue inhibitor of metalloproteinases-like, OB-fold
- Alpha-macroglobulin, receptor-binding domain superfamily
- Alpha-2-macroglobulin
- Anaphylatoxin/fibulin
- Alpha-2-macroglobulin, bait region domain
- Immunoglobulin-like fold
10 more domains
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
C4d-A (preferred)
PDBe Complex ID:
PDB-CPX-142895 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (6 distinct):
Complement C4 beta chain
Molecule details ›
Chain: A
Length: 656 amino acids
Theoretical weight: 71.76 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Length: 656 amino acids
Theoretical weight: 71.76 KDa
Source organism: Homo sapiens
UniProt:
- Canonical:
P0C0L4 (Residues: 20-675; Coverage: 38%)
Sequence domains:
- Complement C4, MG1 domain
- MG2 domain
- Macroglobulin domain MG3
- Macroglobulin domain MG4
- Alpha-2-macroglobulin bait region domain
Complement C4-A alpha chain
Molecule details ›
Chain: B
Length: 767 amino acids
Theoretical weight: 84.27 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Structure domains:
Length: 767 amino acids
Theoretical weight: 84.27 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P0C0L4 (Residues: 680-1446; Coverage: 45%)
Sequence domains:
Structure domains:
Complement C4 gamma chain
Molecule details ›
Chain: C
Length: 290 amino acids
Theoretical weight: 32.99 KDa
Source organism: Homo sapiens
UniProt:
Sequence domains:
Structure domains:
Length: 290 amino acids
Theoretical weight: 32.99 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P0C0L4 (Residues: 1455-1744; Coverage: 17%)
Sequence domains:
Structure domains:
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
SOLEIL BEAMLINE PROXIMA 1, ESRF BEAMLINE ID29
Spacegroup:
P212121
