› 5jxb

X-ray diffraction
2.9Å resolution

PSD-95 extended PDZ3 in complex with SynGAP PBM

Released:
DOI: 10.2210/pdb5jxb/pdb
PDB entry 5jxb coloured by chain, front view.
PDB entry 5jxb coloured by chain, side view.
PDB entry 5jxb coloured by chain, top view.
Source organisms:
Primary publication:
Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity.
Zeng M, Shang Y, Araki Y, Guo T, Huganir RL, Zhang M
Cell 166 1163-1175.e12 (2016)
PMID: 27565345

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125309 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 4; Synaptic Ras GTPase activating protein 1 homolog (rat) Chains: A, C
Molecule details ›
Chains: A, C
Length: 123 amino acids
Theoretical weight: 13.41 KDa
Source organisms: Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P78352 (Residues: 309-413; Coverage: 15%)
  • Canonical: J3QQ18 (Residues: 1297-1308; Coverage: 1%)
Gene names: DLG4, PSD95, Syngap1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 70.286Å b: 71.094Å c: 115.791Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.241 0.287
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

87 review citations

Biomolecular condensates: organizers of cellular biochemistry.
Banani et al. (2017)
86 more

4 mentions without citation

Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity.
Zeng et al. (2016)
3 more