› 5jyn

Solution NMR

Structure of the transmembrane domain of HIV-1 gp41 in bicelle

Released:
DOI: 10.2210/pdb5jyn/pdb
PDB entry 5jyn coloured by chain, ensemble of 15 models, front view.
PDB entry 5jyn coloured by chain, ensemble of 15 models, side view.
PDB entry 5jyn coloured by chain, ensemble of 15 models, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Structural basis for membrane anchoring of HIV-1 envelope spike.
Dev J, Park D, Fu Q, Chen J, Ha HJ, Ghantous F, Herrmann T, Chang W, Liu Z, Frey G, Seaman MS, Chen B, Chou JJ
Science 353 172-175 (2016)
PMID: 27338706

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181017 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope glycoprotein gp160 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 40 amino acids
Theoretical weight: 4.65 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q74849 (Residues: 670-709; Coverage: 5%)
Gene name: env

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 8%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

19 review citations

Molecular Mechanism of HIV-1 Entry.
Chen B. (2019)
18 more

19 mentions without citation

Solution NMR: A powerful tool for structural and functional studies of membrane proteins in reconstituted environments.
Puthenveetil et al. (2019)
18 more