› 5k19

X-ray diffraction
2.6Å resolution

Crystal structure of WD repeat-containing protein 20

Released:
DOI: 10.2210/pdb5k19/pdb
PDB entry 5k19 coloured by chain, front view.
PDB entry 5k19 coloured by chain, side view.
PDB entry 5k19 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20.
Li H, Lim KS, Kim H, Hinds TR, Jo U, Mao H, Weller CE, Sun J, Chatterjee C, D'Andrea AD, Zheng N
Mol Cell 63 249-260 (2016)
PMID: 27373336

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186182 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
WD repeat-containing protein 20 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 569 amino acids
Theoretical weight: 62.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli K-12
UniProt:
  • Canonical: Q8TBZ3 (Residues: 1-569; Coverage: 100%)
Gene name: WDR20
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P31
Unit cell:
a: 120.014Å b: 120.014Å c: 95.307Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.191 0.257
Expression system: Escherichia coli K-12

Quick links

Citations

8 review citations

Mechanisms of Deubiquitinase Specificity and Regulation.
Mevissen et al. (2017)
7 more

1 mention without citation

Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20.
Li et al. (2016)