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X-ray diffraction
1.64Å resolution

Function and Biology Details

Reaction catalysed: 
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 389 amino acids
Theoretical weight: 39.85 KDa
Source organism: Mycolicibacterium thermoresistibile
Expression system: Escherichia coli
UniProt:
  • Canonical: G7CNL4 (Residues: 2-109, 237-513; Coverage: 75%)
Gene names: KEK_23061, guaB
Sequence domains: IMP dehydrogenase / GMP reductase domain
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:
Ligand IMP 1 x IMP
Ligand 6Q8 1 x 6Q8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: I4
Unit cell:
a: 89.27Å b: 89.27Å c: 84.76Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.193 0.2
Expression system: Escherichia coli

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Citations

15 review citations

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.
Hameed et al. (2018)
14 more

3 mentions without citation

Inhibitors of inosine 5'-monophosphate dehydrogenase as emerging new generation antimicrobial agents.
Juvale et al. (2019)
2 more