› 5k5f

Solution NMR

NMR structure of the HLTF HIRAN domain

Released:
DOI: 10.2210/pdb5k5f/pdb
PDB entry 5k5f coloured by chain, ensemble of 20 models, front view.
PDB entry 5k5f coloured by chain, ensemble of 20 models, side view.
PDB entry 5k5f coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Bezsonova I, Neculai D, Korzhnev D, Weigelt J, Bountra C, Edwards A, Arrowsmith C, Dhe-Paganon S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172024 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Helicase-like transcription factor Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14527 (Residues: 51-171; Coverage: 12%)
Gene names: HIP116A, HLTF, RNF80, SMARCA3, SNF2L3, ZBU1
Sequence domains: HIRAN domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: simulated annealing
Expression system: Escherichia coli

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