› 5k6d

X-ray diffraction
1.14Å resolution

Structure of FS50 an antagonist of NaV1.5

Released:
DOI: 10.2210/pdb5k6d/pdb
PDB entry 5k6d coloured by chain, front view.
PDB entry 5k6d coloured by chain, side view.
PDB entry 5k6d coloured by chain, top view.
Source organism: Xenopsylla cheopis
Primary publication:
Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5.
Xu X, Zhang B, Yang S, An S, Ribeiro JM, Andersen JF
Sci Rep 6 36574 (2016)
PMID: 27819327

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106844 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Putative secreted salivary protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 78 amino acids
Theoretical weight: 8.22 KDa
Source organism: Xenopsylla cheopis
Expression system: Escherichia coli
UniProt:
  • Canonical: A2IAD2 (Residues: 20-96; Coverage: 100%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: C2
Unit cell:
a: 60.251Å b: 66.627Å c: 42.285Å
α: 90° β: 121.69° γ: 90°
R-values:
R R work R free
0.168 0.167 0.174
Expression system: Escherichia coli

Quick links

Citations

1 review citation

The Functional Role of Voltage-Gated Sodium Channel Nav1.5 in Metastatic Breast Cancer.
Luo et al. (2020)
6 other articles

1 mention without citation

Structure and Function of FS50, a salivary protein from the flea Xenopsylla cheopis that blocks the sodium channel NaV1.5.
Xu et al. (2016)