› 5khs

X-ray diffraction
3.76Å resolution

Crystal structures of the Burkholderia multivorans hopanoid transporter HpnN

Released:
DOI: 10.2210/pdb5khs/pdb
PDB entry 5khs coloured by chain, front view.
PDB entry 5khs coloured by chain, side view.
PDB entry 5khs coloured by chain, top view.
Source organism: Burkholderia multivorans
Primary publication:
Crystal structures of the Burkholderia multivorans hopanoid transporter HpnN.
Kumar N, Su CC, Chou TH, Radhakrishnan A, Delmar JA, Rajashankar KR, Yu EW
Proc Natl Acad Sci U S A 114 6557-6562 (2017)
PMID: 28584102

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102065 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hopanoid transporter HpnN Chains: A, B
Molecule details ›
Chains: A, B
Length: 883 amino acids
Theoretical weight: 93.5 KDa
Source organism: Burkholderia multivorans
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0H3KP92 (Residues: 1-877; Coverage: 100%)
Gene names: BMULJ_05341, hpnN
Sequence domains: MMPL family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 112.158Å b: 143.374Å c: 112.661Å
α: 90° β: 114.1° γ: 90°
R-values:
R R work R free
0.265 0.263 0.307
Expression system: Escherichia coli

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Citations

9 review citations

Multidrug efflux pumps: structure, function and regulation.
Du et al. (2018)
8 more

4 mentions without citation

Targeting MmpL3 for anti-tuberculosis drug development.
Bolla JR. (2020)
3 more