› 5knw

Solution NMR

Solution NMR structure of human LARP7 xRRM2

Released:
DOI: 10.2210/pdb5knw/pdb
PDB entry 5knw coloured by chain, ensemble of 20 models, front view.
PDB entry 5knw coloured by chain, ensemble of 20 models, side view.
PDB entry 5knw coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
hLARP7 C-terminal domain contains an xRRM that binds the 3' hairpin of 7SK RNA.
Eichhorn CD, Chug R, Feigon J
Nucleic Acids Res 44 9977-9989 (2016)
PMID: 27679474

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175525 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
La-related protein 7 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: Q4G0J3 (Residues: 445-561; Coverage: 20%)
Gene names: HDCMA18P, LARP7
Sequence domains: RNA binding motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'

Quick links

Citations

4 review citations

LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization.
Mattijssen et al. (2021)
3 more

5 mentions without citation

The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.
Maraia et al. (2017)
4 more