› 5ko9

X-ray diffraction
1.5Å resolution

Crystal Structure of the SRAP Domain of Human HMCES Protein

Released:
DOI: 10.2210/pdb5ko9/pdb
PDB entry 5ko9 coloured by chain, front view.
PDB entry 5ko9 coloured by chain, side view.
PDB entry 5ko9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.
Halabelian L, Ravichandran M, Li Y, Zeng H, Rao A, Aravind L, Arrowsmith CH
Nat Struct Mol Biol 26 607-612 (2019)
PMID: 31235913

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188509 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Abasic site processing protein HMCES Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 31.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96FZ2 (Residues: 1-270; Coverage: 76%)
Gene names: C3orf37, DC12, HMCES, SRAPD1
Sequence domains: SOS response associated peptidase (SRAP)
Structure domains: SOS response associated peptidase-like

Ligands and Environments

1 bound ligand:
Ligand UNX 44 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Unit cell:
a: 80.102Å b: 44.745Å c: 82.901Å
α: 90° β: 107.15° γ: 90°
R-values:
R R work R free
0.183 0.182 0.209
Expression system: Escherichia coli

Quick links

Citations

6 review citations

AID in Antibody Diversification: There and Back Again.
Feng et al. (2020)
5 more

7 mentions without citation

Structural biology of DNA abasic site protection by SRAP proteins.
Amidon et al. (2020)
6 more