› 5kpj

X-ray diffraction
3.5Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149243 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent translocase ABCB1 Chain: A
Molecule details ›
Chain: A
Length: 1282 amino acids
Theoretical weight: 141.72 KDa
Source organism: Mus musculus
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: P21447 (Residues: 1-1276; Coverage: 100%)
Gene names: Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand M3L 2 x M3L

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 88.646Å b: 137.17Å c: 186.087Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.287 0.286 0.315
Expression system: Komagataella phaffii GS115

Quick links

Citations

25 review citations

Revisiting the role of ABC transporters in multidrug-resistant cancer.
Robey et al. (2018)
24 more

6 mentions without citation

Structural and functional diversity calls for a new classification of ABC transporters.
Thomas et al. (2020)
5 more