› 5kql

X-ray diffraction
1.45Å resolution

Co-crystal structure of LMW-PTP in complex with 2-oxo-1-phenyl-2-(phenylamino)ethanesulfonic acid

Released:
DOI: 10.2210/pdb5kql/pdb
PDB entry 5kql coloured by chain, front view.
PDB entry 5kql coloured by chain, side view.
PDB entry 5kql coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.
He R, Wang J, Yu ZH, Zhang RY, Liu S, Wu L, Zhang ZY
J Med Chem 59 9094-9106 (2016)
PMID: 27676368

Function and Biology Details

Reactions catalysed: 
A phosphate monoester + H(2)O = an alcohol + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150269 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low molecular weight phosphotyrosine protein phosphatase Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 20.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P24666 (Residues: 1-158; Coverage: 100%)
Gene name: ACP1
Sequence domains: Low molecular weight phosphotyrosine protein phosphatase
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand 6VY 1 x 6VY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P212121
Unit cell:
a: 34.19Å b: 54.573Å c: 97.515Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.164 0.176
Expression system: Escherichia coli BL21(DE3)

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Citations

6 review citations

Targeting Tyrosine Phosphatases: Time to End the Stigma.
Stanford et al. (2017)
5 more

1 mention without citation

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism.
He et al. (2016)