› 5kuh

Electron Microscopy
11.6Å resolution

GluK2EM with LY466195

Released:
DOI: 10.2210/pdb5kuh/pdb
PDB entry 5kuh coloured by chain, front view.
PDB entry 5kuh coloured by chain, side view.
PDB entry 5kuh coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis of kainate subtype glutamate receptor desensitization.
Meyerson JR, Chittori S, Merk A, Rao P, Han TH, Serpe M, Mayer ML, Subramaniam S
Nature 537 567-571 (2016)
PMID: 27580033
Related structures: EMD-8290

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 757 amino acids
Theoretical weight: 85.53 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P42260 (Residues: 32-544, 667-908; Coverage: 86%)
Gene names: Glur6, Grik2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand LY5 4 x LY5
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 11.6Å
Relevant EMDB volumes: EMD-8290
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert.
Reiner et al. (2018)
13 more

6 mentions without citation

Structural basis of kainate subtype glutamate receptor desensitization.
Meyerson et al. (2016)
5 more