Function and Biology Details
Reactions catalysed:
(1a) L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero 36-mer (preferred)
PDBe Complex ID:
PDB-CPX-172518 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Cysteine desulfurase
Molecule details ›
Chains: 1, 2, 3, 4, M, N, O, P, Q, R, S, T
Length: 391 amino acids
Theoretical weight: 43.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli #1/H766
UniProt:
Sequence domains: Aminotransferase class-V
Length: 391 amino acids
Theoretical weight: 43.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli #1/H766
UniProt:
- Canonical:
Q9Y697 (Residues: 67-457; Coverage: 86%)
Sequence domains: Aminotransferase class-V
Frataxin intermediate form
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 169 amino acids
Theoretical weight: 18.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli #1/H766
UniProt:
Sequence domains: Frataxin-like domain
Length: 169 amino acids
Theoretical weight: 18.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli #1/H766
UniProt:
- Canonical: Q16595 (Residues: 42-210; Coverage: 81%)
Sequence domains: Frataxin-like domain
Iron-sulfur cluster assembly enzyme ISCU
Molecule details ›
Chains: a, b, c, d, e, f, g, h, i, j, k, l
Length: 118 amino acids
Theoretical weight: 12.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli #1/H766
UniProt:
Sequence domains: NifU-like N terminal domain
Length: 118 amino acids
Theoretical weight: 12.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli #1/H766
UniProt:
- Canonical: Q9H1K1 (Residues: 50-167; Coverage: 71%)
Sequence domains: NifU-like N terminal domain
