5l36

X-ray diffraction
3.1Å resolution

Crystal Structure of a human FasL mutant in complex with human DcR3

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-131928 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor receptor superfamily member 6B Chain: B
Molecule details ›
Chain: B
Length: 174 amino acids
Theoretical weight: 19.04 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: O95407 (Residues: 30-195; Coverage: 61%)
Gene names: DCR3, TNFRSF6B, TR6, UNQ186/PRO212
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2
Tumor necrosis factor ligand superfamily member 6, soluble form Chain: A
Molecule details ›
Chain: A
Length: 153 amino acids
Theoretical weight: 17.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli-Pichia pastoris shuttle vector pPpB1_S
UniProt:
  • Canonical: P48023 (Residues: 130-281; Coverage: 54%)
Gene names: APT1LG1, CD95L, FASL, FASLG, TNFSF6
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: R32
Unit cell:
a: 127.267Å b: 127.267Å c: 206.262Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.178 0.223
Expression systems:
  • Drosophila
  • Escherichia coli-Pichia pastoris shuttle vector pPpB1_S