We've built a new version of this page with an interactive 3D viewer. Try it out in beta and help us improve:

› 5l3o

X-ray diffraction
1.98Å resolution

Crystal Structure of Human Carbonic Anhydrase II in Complex with a Quinoline Oligoamide Foldamer

Released:
DOI: 10.2210/pdb5l3o/pdb
Model geometry
Fit model/data
PDB entry 5l3o coloured by chain, front view.
PDB entry 5l3o coloured by chain, side view.
PDB entry 5l3o coloured by chain, top view.
Source organisms:
Primary publication:
Self-Assembled Protein-Aromatic Foldamer Complexes with 2:3 and 2:2:1 Stoichiometries.
Jewginski M, Granier T, Langlois d'Estaintot B, Fischer L, Mackereth CD, Huc I
J Am Chem Soc 139 2928-2931 (2017)
PMID: 28170240

Function and Biology Details

Reactions catalysed: 
hydrogencarbonate + H(+) = CO2 + H2O.
urea = cyanamide + H2O.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-250959 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Carbonic anhydrase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase
Aromatic foldamer Chains: C, D, E, F
Molecule details ›
Chains: C, D, E, F
Length: 6 amino acids
Theoretical weight: 1.34 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand GOL 7 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 158.88Å b: 54.48Å c: 84.92Å
α: 90° β: 112.79° γ: 90°
R-values:
R R work R free
0.208 0.207 0.236
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

7 citation in other articles

Supramolecular Chemistry Targeting Proteins.
van Dun et al. (2017)
6 more

PDB-REDO

The sliders below show the change in model quality between original PDB entry and the PDB-REDO entry

Model Geometry
 
 
Data not available
DNA/RNA Geometry
 
 
Data not available
Fit model/data
 
 
Data not available
PDB-REDO