Function and Biology Details
Reactions catalysed:
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H(2)O
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130690 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phospholipid hydroperoxide glutathione peroxidase GPX4
Molecule details ›
Chain: A
Length: 171 amino acids
Theoretical weight: 19.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains: Glutathione peroxidase
Structure domains: Glutaredoxin
Length: 171 amino acids
Theoretical weight: 19.56 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
O70325 (Residues: 29-197; Coverage: 86%)
Sequence domains: Glutathione peroxidase
Structure domains: Glutaredoxin
