› 5ljl

X-ray diffraction
1.6Å resolution

Streptococcus pneumonia TIGR4 flavodoxin: structural and biophysical characterization of a novel drug target

Released:
DOI: 10.2210/pdb5ljl/pdb
PDB entry 5ljl coloured by chain, front view.
PDB entry 5ljl coloured by chain, side view.
PDB entry 5ljl coloured by chain, top view.
Source organism: Streptococcus pneumoniae TIGR4
Primary publication:
Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target.
Rodríguez-Cárdenas Á, Rojas AL, Conde-Giménez M, Velázquez-Campoy A, Hurtado-Guerrero R, Sancho J
PLoS One 11 e0161020 (2016)
PMID: 27649488

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184131 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Flavodoxin Chain: A
Molecule details ›
Chain: A
Length: 149 amino acids
Theoretical weight: 16.16 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8DPG4 (Residues: 1-147; Coverage: 100%)
Gene names: flaV, spr1175
Sequence domains: Flavodoxin
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 29.871Å b: 60.707Å c: 61.803Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.174 0.173 0.215
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Flavodoxins as Novel Therapeutic Targets against Helicobacter pylori and Other Gastric Pathogens.
Salillas et al. (2020)
4 other articles

1 mention without citation

Streptococcus pneumoniae TIGR4 Flavodoxin: Structural and Biophysical Characterization of a Novel Drug Target.
Rodríguez-Cárdenas et al. (2016)