› 5lor

X-ray diffraction
2.19Å resolution

human NUDT22

Released:
DOI: 10.2210/pdb5lor/pdb
PDB entry 5lor coloured by chain, front view.
PDB entry 5lor coloured by chain, side view.
PDB entry 5lor coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Carter M, Stenmark P

Function and Biology Details

Reaction catalysed: 
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189691 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uridine diphosphate glucose pyrophosphatase NUDT22 Chains: A, B
Molecule details ›
Chains: A, B
Length: 330 amino acids
Theoretical weight: 35.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BRQ3 (Residues: 1-303; Coverage: 100%)
Gene names: NUDT22, PP11246

Ligands and Environments

1 bound ligand:
Ligand UPG 1 x UPG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 52.332Å b: 46.565Å c: 120.678Å
α: 90° β: 94.27° γ: 90°
R-values:
R R work R free
0.203 0.2 0.244
Expression system: Escherichia coli BL21(DE3)

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