Function and Biology Details
Reaction catalysed:
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
OTU domain-containing protein 7B and Ubiquitin (preferred)
PDBe Complex ID:
PDB-CPX-143275 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
OTU domain-containing protein 7B
Molecule details ›
Chains: A, C
Length: 296 amino acids
Theoretical weight: 34.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: OTU-like cysteine protease
Length: 296 amino acids
Theoretical weight: 34.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q6GQQ9 (Residues: 129-266, 292-438; Coverage: 34%)
Sequence domains: OTU-like cysteine protease
Ubiquitin
Molecule details ›
Chains: B, D
Length: 76 amino acids
Theoretical weight: 8.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ubiquitin family
Length: 76 amino acids
Theoretical weight: 8.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P0CG47 (Residues: 153-227; Coverage: 33%)
Sequence domains: Ubiquitin family
