› 5lv6

Solution NMR

N-terminal motif dimerization of EGFR transmembrane domain in bicellar environment

Released:
DOI: 10.2210/pdb5lv6/pdb
PDB entry 5lv6 coloured by chain, ensemble of 20 models, front view.
PDB entry 5lv6 coloured by chain, ensemble of 20 models, side view.
PDB entry 5lv6 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The Conformation of the Epidermal Growth Factor Receptor Transmembrane Domain Dimer Dynamically Adapts to the Local Membrane Environment.
Bocharov EV, Bragin PE, Pavlov KV, Bocharova OV, Mineev KS, Polyansky AA, Volynsky PE, Efremov RG, Arseniev AS
Biochemistry 56 1697-1705 (2017)
PMID: 28291355

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132701 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 44 amino acids
Theoretical weight: 4.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00533 (Residues: 634-677; Coverage: 4%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains: Epidermal growth factor receptor transmembrane-juxtamembrane segment

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 46%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Therapeutic targeting of the angiopoietin-TIE pathway.
Saharinen et al. (2017)
5 more

6 mentions without citation

Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.
Muller et al. (2019)
5 more