› 5lxb

X-ray diffraction
2.34Å resolution

Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with palonosetron

Released:
DOI: 10.2210/pdb5lxb/pdb
PDB entry 5lxb coloured by chain, front view.
PDB entry 5lxb coloured by chain, side view.
PDB entry 5lxb coloured by chain, top view.
Source organism: Aplysia californica
Primary publication:
Palonosetron-5-HT3 Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.
Price KL, Lillestol RK, Ulens C, Lummis SC
ACS Chem Neurosci 7 1641-1646 (2016)
PMID: 27656911

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186694 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 242 amino acids
Theoretical weight: 27.53 KDa
Source organism: Aplysia californica
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q8WSF8 (Residues: 1-236; Coverage: 100%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

2 bound ligands:
Ligand NAG 8 x NAG
Ligand 7A9 7 x 7A9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 72.215Å b: 137.051Å c: 131.249Å
α: 90° β: 93.78° γ: 90°
R-values:
R R work R free
0.219 0.218 0.245
Expression system: Spodoptera frugiperda

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Citations

1 review citation

Immunomodulatory Action of Substituted 1,3,4-Thiadiazines on the Course of Myocardial Infarction.
Sarapultsev et al. (2018)
6 other articles